Together, these findings imply that the protein–protein interaction portion of the overall association energy may be separable from the contributions arising from protein–lipid and lipid–lipid energy terms. A comparison of the dimer stability between different hydrophobic environments suggested that the hierarchy of stability for sequence variants is conserved. Inspection of the NMR structure indicates that simple principles of protein–protein interactions can explain the changes in energy that are observed. Our study further revealed that the energy of association is not evenly distributed across the interface, but that there are several “hot spots” for interaction including both glycines participating in a GxxxG motif. In contrast, mutations to alanine away from the dimer interface showed free energies of association that are insignificantly different from wild-type or are slightly stabilizing. In all cases, we found that mutations to alanine at interface positions cost free energy of association. To understand the energetic principles of these helix–helix interactions, we have used alanine-scanning mutagenesis and sedimentation equilibrium analytical ultracentrifugation to quantitatively examine the sequence dependence of the glycophorin A transmembrane helix dimerization. Sitecore Experience Commerce, your Helix compliant solution will containĬode that gets executed on both the website and the commerce engine.The folding, stability, and oligomerization of helical membrane proteins depend in part on a precise set of packing interactions between transmembrane helices. To the sites running in the customer’s implementation. Commerce Engine The Commerce Engine is the subsystem used to provide eCommerce functionality Modules, features and functionalities developed and deployed to solve Implementation An implementation, or customer implementation, is the total number of Website A website is a site that can output content to the web channel. which assets the business logic can access. Sitecore, technically a site is a context under which content is output, To any channel, not necessarily as a website to the web channel. Objective, and sharing a common set of assets. Site A collection of content and output with a common overall business Which allows certain resources to be shared (such as templates andĭigital assets), while allowing other resources (such as sites and otherīusiness entities) to be defined and managed independently (see Multi-site and multi-tenant). Sitecore allows multiple tenants to share a single implementation, Tenant A product owner of one or more sites in a Sitecore implementation. Languages and used in the UX, for example on websites, Sitecore tools,Į-mails, etc. Dictionary A collection of named text snippets which can be translated across Assets Technically an Asset refers to a digital asset such as images, but canĪlso mean the actual output from any process or task in your entireĪpplication lifecycle: code, files, visual design, data, content,Ĭonfiguration changes, deployment packages etc. Serialization The process of writing data in the Sitecore databases to disk so that itĬan maintained in version control and packaged into deployments acrossĮnvironments. Which is a project that will result in new features being added to hisĬompany’s website. The five Visual Studio projects that contain the code that powers hisĬompany’s Sitecore solution. Most of his time is spent working in one of ![]() For example, Michael is aĭeveloper at his company. Project In technical terms, project often refers to Visual Studio project, butĬonceptually can also to the process of implementing the business Visual Studio solution that contains the code that powers his company’s Solution Technically often refers to Visual Studio solution, but conceptually, itĬan also refer to an implementation. Which contains functionality that runs on both the Sitecore website and theĬommerce Engine. ![]() These assets can also span across the different target services that make Logic and configuration relating to search belongs to the Search module. Their Sitecore solution contains website search, all assets, business The conventions, processes and tools described in thisĭocument relate to managing all these assets in a module-centric – and Definitions ¶ Module A Module is a conceptual grouping of assets which relates to a business
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